Post-doctoral position on Leptospira virulence at Institut Pasteur

Application Deadline 01 Oct 2026 2026-10-01 8:00:00 2026-10-01 18:00:00 Europe/Paris Post-doctoral position on Leptospira virulence at Institut Pasteur Post-Doctoral Researcher Position at the Institut Pasteur in ParisOpen position at the Biology of Spirochetes Unit, https://research.pasteur.fr/en/team/biology-of-spirochetes/ in the department of Microbiology. Dive into the Fascinating World of Spirochetes !Join us in uncovering what […] "25-28 rue du Dr. Roux, 75015, Paris" Mathieu Picardeau mathieu.picardeau@pasteur.fr Add to Calendar iCalendar Google Calendar Outlook Outlook Online Yahoo! Calendar iCalendar Google Calendar Outlook Outlook Online Yahoo! Calendar Post-Doctoral Researcher Position at the Institut Pasteur in Paris Open position at the Biology of Spirochetes Unit, https://research.pasteur.fr/en/team/biology-of-spirochetes/ in the department of Microbiology. Dive into the Fascinating World of Spirochetes ! Join us in uncovering what makes Leptospira pathogenic to humans. Contribute to cutting-edge research and help advance our understanding of this important bacterial pathogen. Project Overview Leptospirosis is a re-emerging zoonotic disease of increasing public health concern, a situation further exacerbated by climate change. Leptospira interrogans, the causative agent of leptospirosis, offers an excellent model for studying the mechanisms underlying host adaptation and zoonotic emergence. Virtually all mammalian species can act as reservoirs for this pathogen, with individual serovars exhibiting adaptation to specific host reservoirs. Among pathogenic Leptospira, strains of the Icterohaemorrhagiae serogroup are associated with the most severe and frequently fatal clinical outcomes. However, the bacterial determinants underlying this increased virulence remain poorly understood. Through an integrated approach, this project will not only reveal fundamental mechanisms of host specialization, but will also provide a comprehensive effort to elucidate the exceptional virulence of Icterohaemorrhagiae strains. Your Role You’ll work closely with other collaborative teams, bridging the gap between cell biology, genomics and pathogenesis. With your expertise in cell biology (cell culture of human primary cells), you will characterize the mechanisms of host-adaptation of pathogenic Leptospira. Qualification An expertise in cell biology, molecular biology, transcriptomic and genomic analysis, imaging and/or infectious models will be appreciated. Starting Date & Duration This position is available in October 2026 for a minimum of 2 years, renewable. Location: The Institut Pasteur (https://www.pasteur.fr/en) is a world-renowned center of excellence for its research in biology, infectious diseases and immunology. The Institut Pasteur is located in the center of Paris and offers outstanding research facilities, including state-of-the-art imaging and omics, providing cutting edge technologies. The Biology of Spirochetes unit also hosts the French National Reference Center for Leptospirosis and a WHO Collaborating Center for Reference and Research on Leptospirosis. How To Apply Send your CV and a motivation letter with at least two references to: mathieu.picardeau@pasteur.fr References In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen. Giraud-Gatineau A, Haustant G, Monot M, Picardeau M, Benaroudj N. Nat Commun. 2026;17:2274. doi: 10.1038/s41467-026-69033-8. PMID: 41634022 Evolutionary insights into the emergence of virulent Leptospira spirochetes. Giraud-Gatineau A, Nieves C, Harrison LB, Benaroudj N, Veyrier FJ, Picardeau M. PLoS Pathog. 2024 20:e1012161. doi: 10.1371/journal.ppat.1012161. PMID: 39018329 Host adaptation drives genome evolution and virulence diversification in a bacterial zoonotic pathogen. Giraud-Gatineau A, Weke K, Ouazahrou R, Pulido F, Monot M, Benaroudj N, Veyrier F, Petrosova H, Picardeau M. BioRxiv 2026.06.29.734755; doi: https://doi.org/10.64898/2026.06.29.734755 You might be interested in Postdoctoral position in cellular and circuit neuroscience Job Engineer position available in single-cell • omics analyses Job TRamWAy Postdoctoral fellowship Job POST-DOCTORAL POSITION TO STUDY VIRAL MECHANISMS OF MEMBRANE RUPTURE AND REPAIR Job Probing neural computation in an insect “brain” (M2 internship – PhD – postdoctoral fellowship) Job POST-DOCTORAL POSITION in IMMUNOLOGY: Evaluating novel immune modulating therapies in HBV infections. Job Seminar Dept Microbiology “Bacterial adaptation to oxidative stress: beyond classic oxidants” Event Macha DUSSOUCHAUD PhD Defense “Study of the ancestral iron-sulfur biogenesis machineries, MIS and SMS” Event “Relevance of gut microbiota in oncology”, Laurence Zitvogel Event PICKY EATERS: HOW MACROPHAGES SELECT TARGETS FOR PHAGOCYTOSIS Event (Workshop)Value-up your idea 2026 on June 5 & 12, 2026 Event Les Webinaires de l’Enseignement – Fièvre Hémorragique de Crimée-Congo une menace émergente en Europe et en France – Simon Bessis Event Improving immunotherapies for blood cancers: real-time exploration in the tumor News Virology afternoons – dedicated to Pasteurian scientists News Congratulation to Alain Jacquier for receiving the Prix André Goffeau – 2021 Medal of the Société Française de Génétique News Nouvelle étudiante Licence en alternance News Hot off the press News IDMI-DIM1Health Symposium News Published on: 09 Jul 2026